There have been many important innovations in the landscape of vaccine development for neglected and emerging infectious diseases, such as the launch of public-private product development partnerships (PDPs). However, there is still a gap in funding the development of such vaccines, especially when it comes to financing late-stage trials. There is a financial risk in investing in late-stage trials, and there is no guarantee of a commercial market, particularly for the most neglected diseases of poverty. One result of the funding gap is that there are many infectious diseases with a high burden in the Asia-Pacific region for which there are no licensed, highly effective vaccines, including HIV/AIDS, tuberculosis, soil-transmitted helminths and schistosomiasis. There are also neglected infectious diseases that affect populations in the region where the existing vaccines have limitations, such as malaria, dengue, and Japanese encephalitis.