After 13 ( 15 in 2014 at the time of departure) years of unsuccessful war , US withdrawal may cause a major political,security and strategic vacuum in Afghanistan , which may not only further deteriorate the situation of Afghanistan but also cause many problems in neighbouring and regional countries. These countries have their own political, economical and security interests and objectives in Afghanistan. Therefore, these countries will try to influence Afghanistan in many ways after the departure. Therefore, the interests, role and strategy of Pakistan, India, Russia, Iran, China and Turkey has been analysed in detail in this paper. This paper also discusses different partnerships which emerge in Afghanistan after the exit of the US and allied forces.