Southeast Asia countries were developing countries, with the rapid development for a better living condition leads to longer life expectancy, which increased total population. It may result in increased the demand of pharmaceutical in domestic use and or in hospital. Although most wastewater treatment plants (WWTPs) met the local authority’s regulatory requirement, there are still many pharmaceutical compound incompletely removed and discharge to the water stream and enter the environment. Recently many studies and researches have published on the occurrence and source as well as the fate of pharmaceuticals all over the world including Asia. As part of Asia region, Southeast Asia countries (Malaysia, Philippines, Singapore, Thailand, Vietnam, Brunei, Cambodia, and Lao PDR) seem has lack of research knowledge and information regarding this emerging pollutant issues compared to developed Asia country as China, Korea and Hong Kong. In this paper, it will review recent studies occurrences (surface and wastewater) on most common pharmaceuticals with several recommendations to overcome and thus summarise the actual situation in Southeast Asia.