연구정보
A New Phloroglucinol Derivative Isolated from Hypericum afrum, a Plant Endemic to Algeria
알제리 국외연구자료 기타 Farida Larit, Francisco León, Narayan D. Chaurasiya, Babu L. Tekwani, Samira Benyahia, Samir Benayache, Stephen J.Cutler Records of Natural Products 발간일 : 2017-01-11 등록일 : 2017-02-28 원문링크
A new phloroglucinol derivative, identified as 3-benzoyl-3-hydroxy-5-(3-methylbut-2-en-1-yl)cyclopentane-1,2,4-trione (1 ), together with eight previously reported compounds, quercetin, myricitrin, hypericin, biapeginin, pseudohypericin, myricetin, 1,3,5,6-tetrahydroxyxanthone, and β-sitosterol were isolated from the chloroform, ethyl acetate and butanol extracts of the aerial part of Hypericum afrum (Lam.). Their structures were elucidated by spectroscopic analyses, including 1D-, 2D-NMR and HRESIMS. The EtOAc extract showed moderate MAO-A inhibition with an IC 50 value of 3.35 μg/mL. Bioassay-guided fractionation of the EtOAc extract resulted in the isolation of quercetin as the active component exhibiting MAO-A inhibitory activity with an IC 50 value of 1.25 μM.
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