Use of information technology in providing efficient library services is inevitable in today’s information world. Its implementation causes many challenges for all the stake holders. This study is an attempt to identify challenges faced by university libraries of Pakistan in information technology adoption. To elucidate the research problem, a combination of quantitative and qualitative research methods was used. Valid returned questionnaires (N=52) and recorded interviews of 51 LIS professionals with experience in library automation were analyzed to draw the results. The study determined that ‘lack of training opportunities for LIS professionals’ and ‘lack of IT skills among the majority of LIS professionals’ are major challenges to the adaptation of IT. Similarities were found in the results of this study and some previous studies conducted at national and international levels.