Nearly a century after Afghanistan gained independence in 1919, the question of autonomy and originality in the nation's 20th-century foreign policy remains a topic of contention within the country. Following its independence, Afghanistan found itself in a unique situation shaped by the influence of major global powers' competition. Over the past century, geopolitical shifts have significantly influenced both the internal and external circumstances of Afghanistan. This article seeks to address the query: How did regional geopolitical developments impact Afghanistan's foreign policy from the time of its independence to the events of September 11, 2001? This article is descriptive-analytical in which the relationship between the geopolitics of the region and Afghanistan's foreign policy is examined. The geopolitical situation of Afghanistan in the geopolitical theory of the world order of Saul Cohen has shaped the theoretical discussion of the author, Afghanistan as a quasi-independent state in the geopolitics of the region, not just in the post-Cold War period. The special feature of Afghanistan in the region has been prominent since the independence of this country until now. The findings of this paper show that the foreign policy of Afghanistan after independence in the phases of geopolitical stability and transformations in the security structure of the region is more towards a neutral and balanced strategy. The country has had relations with the great powers of every period and has always distanced itself from such a strategy. It is and the independent or what was once a semi-independent position in the regional geopolitics has evolved into a pivotal and crucial region with the accompanying strategy with great power, coup, revolution and even military occupation has also occurred in this country.