Since the Doi Moi policy of economic reform in 1986, Vietnam has experienced economic development and housing market growth with increasing foreign direct investment. While high-end apartment development has dominated since the emergence of the privatized housing market, more recent focus is on the affordable apartment segment with the remarkable surge of middle-income households in Ho Chi Minh City (HCMC). While most previous studies have analyzed housing price determinants based on locational classification, this study is based on the affordability framework of the housing market in HCMC. It aims to investigate the price determinants of affordable and unaffordable apartment units using the hedonic regression model. The study identified common factors between the two types of apartments, such as vertical shared access and proximity to downtown, as well as unique factors for each, such as more high-rise towers, foreign development, proximity to main roads, and shopping malls only for the affordable segments. The findings have valuable implications, not only for future investors and developers in setting up successful housing development strategies, but also for the public sector in strongly encouraging public–private partnerships for sustainable housing development in Vietnam.