The purpose of the study is examining Istanbul to find out whether or not it has the ability to become an appropriate location to host regional treasury centers. Hence; Simkova’s 11 location criteria are compared across Istanbul additionally Hong Kong and Singapore, being already attractive locations in South East Asia for multinational corporations to set up their regional finance offices, to specify Istanbul’s weaker facilities even if it is not regarded as a rival for Hong Kong and Singapore. The study contributes to the understanding of Simkova’s location criteria assessment before establishing a regional treasury center in any location, as it is applied to some European countries and three Asian countries: Brunei, Hong Kong and Singapore, previously. Lastly, it is concluded that Istanbul is not as superior as Hong Kong and Singapore but it has reasonable conditions to become an attractive location for regional treasury centers.