In each disaster response done by volunteers, sometimes there are emerging issues of religious dissemination and the volunteers are expulsed because of breaching the local values. The use of mosque and local leaders are also supposed to have such issues. Inmanycases, the framework of interfaith and local culture sperspectiveis often forgotten. The issue is how to implement of humanitarian activity based on the interfaith and local cultures perspective? This is a qualitative research using in-depth interviews, observation, focus group discussions, and documentation insix locations. Those locations that found the basis of humanitarian activity, particularly in the role of mosques and the development of the effectiveness of local leaders, as well as have reliedon interfaith and the local culture perspective. This theoretical construction can be apart of the strategic formulation and code of conduct for humanitarian organizations when dealing with communities from different religions and cultures..